Rehabilitation of the severely resorbed maxilla by using quad zygomatic implant-supported prostheses: a systematic review and meta-analysis (2023)

Table of Contents
The Journal of Prosthetic Dentistry Abstract Statement of problem Purpose Material and methods Results Conclusions Section snippets Material and methods Results Discussion Conclusions CRediT authorship contribution statement Implants in the zygomatic bone for maxillary prosthetic rehabilitation: a systematic review Int J Oral Maxillofac Surg Reliability of four zygomatic implant-supported prostheses for the rehabilitation of the atrophic maxilla: a systematic review Int J Oral Maxillofac Implants Immediate full-arch rehabilitation of the severely atrophic maxilla supported by zygomatic implants: a prospective clinical study with minimum follow-up of 6 years Int J Oral Maxillofac Implants Quad zygoma: technique and realities Oral Maxillofac Clin North Am Immediate stabilization at stage II of zygomatic implants: rationale and technique JProsthet Dent Remote implant anchorage for the rehabilitation of maxillary defects JProsthet Dent Reconstruction of the atrophic maxilla with interpositional bone grafting/Le fort I osteotomy and endosteal implants: a 11-16 year follow-up Int J Oral Maxillofac Surg Varying treatment strategies for reconstruction of maxillary atrophy with implants: results in 98 patients JOral Maxillofac Surg 10-year follow-up of onlay bone grafts and implants in severely resorbed maxillae Int J Oral Maxillofac Surg Areview of residual ridge resorption and bone density JProsthet Dent Use of zygomatic implants to deal with resorbed posterior maxillae Periodontol 2000 Zygomatic implants/fixture: a systematic review JOral Implantol The rehabilitation of the severely resorbed maxilla by simultaneous placement of autogenous bone grafts and implants: a 10-year evaluation Clin Oral Investig Effectiveness of sinus lift procedures for dental implant rehabilitation: a Cochrane systematic review Eur J Oral Implantol The zygomatic fixture: clinical procedures Zygoma implants for midfacial prosthetic rehabilitation using telescopes: 9-year follow-up Int J Prosthodont Zygoma fixture in the management of advanced atrophy of the maxilla: technique and long-term results Scand J Plast Reconstr Surg Hand Surg Immediate function of four zygomatic implants: a one-year report of a prospective study Eur J Oral Implantol Reconstruction of the premaxilla with autogenous iliac bone in combination with osseointegrated implants Int J Oral Maxillofac Implants The zygomaticus fixture: an alternative approach for implant anchorage in the posterior maxilla Ann R Australas Coll Dent Surg Zygomatic implants: indications, techniques and outcomes, and the zygomatic success code Periodontol 2000 Preferred reporting items for systematic reviews and meta-analyses: the Prisma statement PLoS Med Clinical outcome of 42 patients treated with 81 immediately loaded zygomatic implants: a 12-to 42-month retrospective study Eur J Oral Implantol Restoration of the edentulous maxilla using extrasinus zygomatic implants combined with anterior conventional implants: a retrospective study Int J Oral Maxillofac Implants Prostheses supported by four immediately loaded zygomatic implants: a 3-year prospective study Eur J Oral Implantol Three-dimensional finite element analysis of zygomatic implants for rehabilitation of patients with a severely atrophic maxilla Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry Biomechanical evaluation of custom-made short implants with wing retention applied in severe atrophic maxillary posterior region restoration: A three-dimensional finite element analysis Specially designed and CAD/CAM manufactured allogeneic bone blocks using for augmentation of a highly atrophic maxilla show a stable base for an all-on-six treatment concept: a case report Misfit of Implant-Supported Zirconia (Y-TZP) CAD-CAM Framework Compared to Non-Zirconia Frameworks: A Systematic Review Rehabilitation of Patients with Compromised Ridge Support Using Immediately Loaded Corticobasal Implant-supported Prostheses: A Prospective Observational Study Zygomatic Implants Operative Consideration to Minimize Technical Errors, Complications, and Their Management The Zygoma Anatomy-Guided Approach for Placement of Zygomatic Implants Virtual quad zygoma implant placement using cone beam computed tomography: sufficiency of malar bone volume, intraosseous implant length, and relationship to the sinus according to the degree of alveolar bone atrophy Quad Zygoma: Technique and Realities Real-Time Navigation in Zygomatic Implant Placement: Workflow Application of Real-Time Surgical Navigation for Zygomatic Implant Insertion in Patients With Severely Atrophic Maxilla

The Journal of Prosthetic Dentistry

Available online 14 December 2021

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Abstract

Statement of problem

Quad zygomatic implants have been used as a treatment option for patients with a severely resorbed maxilla. However, data on the average rate of success of the prosthesis, survival of the zygomatic implants, and associated complications are sparse.

Purpose

The purpose of this systematic review and meta-analysis was to assess prosthetic and zygomatic implant success of treating severe maxillary resorption with prostheses supported by 4 zygomatic implants, with an additional review on potential complications.

Material and methods

A comprehensive search of studies published in English between January 2001 and December 2020 was performed in the PubMed, OVID, EBSCO, and EMBASE databases according to the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines. The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO ID: CRD42021219468). The population, intervention, comparison, and outcome (PICO) question was“What is the effectiveness of oral rehabilitations using only 4 zygomatic implants placed in severely resorbed maxillae?” The search results were subjected to a systematic review for articles reporting prosthetic success and zygomatic implant survival. Prosthetic success was analyzed by using a fixed-effects inverse-variance model. The random-effects model was adopted for meta-analysisas moderate heterogeneity was identified among studies that reported implant survival in quad zygoma treatments. The quality of publications was appraised by using the Critical Appraisal Skills Program (CASP) checklists.

Results

Of the 82 titles, 7 studies that met the inclusion criteria without an overlap of patient cohorts were quantitatively analyzed for the average rate of prosthetic success and implant survival. All prostheses in the aggregated studies were immediately loaded with acrylic resin interim prostheses replaced by a definite prosthesis, which consisted of overdentures retained by bar splinting (n=2), metal bar–reinforced prostheses (n=2), fixed screw–retained acrylic resin prostheses (n=34), and screw-retained titanium prostheses with ceramic or acrylic resin teeth (n=75). Technical complications of zygomatic implants included mobility associated with a machined surface and fracture of the abutment screw. The most common prosthetic complications reported were fracture of the definitive prosthesis and loss of the interim prosthesis subsequent to the failure of at least 1 zygomatic implant. The results showed that prostheses supported by quad zygoma implants displayed an overall success of 100% (CI=95%, I2=0.00%, P=.850), whereas zygomatic implants showed a survival rate of 98% (CI=95%, I2=60.48%, P=.040) with minimal implant failures and few complications.

Conclusions

Although the data analysis showed favorable results for rehabilitating severely resorbed maxillae by using quad zygoma with high prosthetic success and high implant survival rate, further long-term clinical studies are required to strengthen the evidence. However, potential implant and prosthetic complications should be considered while planning this treatment approach.

Section snippets

Material and methods

This systematic review was developed according to the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines.19 The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (Registration number: CRD42021219468).

An electronic search for literature published between 2001 and 2020 in databases including PubMed, OVID, EBSCO, and EMBASE was carried out by 2 reviewers (K.G.V., N.K.). The search strategy used to search for

Results

The initial database search identified 82 articles, from which 28 duplicate articles were removed. Titles and abstracts of the remaining 54 articles were assessed for potentially relevant studies that met the inclusion criteria. Studies that specified rehabilitation with 4 zygomatic implants were included. A total of 18 articles were selected for full-text screening. Of these, 8 articles did not fulfill the inclusion criteria.

(Video) A Patient With An Edentulous Maxilla And Medium Bone Density – Immediate Function - Full video.

Of the 10 remaining articles, Davó etal14,20,22, 23, 24 reported

Discussion

The data in this study suggested that the quad zygomatic approach is an effective treatment option for patients with a severely resorbed maxilla. The studies were assessed based on CI percentage, and none of the studies reported a CI less than 95% (α=.05), thereby rejecting the null hypothesis. Zygomatic implants have been documented in the literature as an alternative treatment to bone augmentation procedures such as guided bone regeneration or distraction osteogenesis, which aims to obtain

Conclusions

Based on the findings of this systematic review and meta-analyses, the following conclusions were drawn:

  • 1.

    The quad zygoma approach for restoring severely resorbed maxilla is a successful and effective treatment modality with an average success rate of 98% [0.96, 1.00] (I2=56.38%, P=.040) for zygomatic implants.

  • 2.

    Prostheses supported by 4 zygomatic implants had an overall success of 100% [0.99, 1.01] (I2=0.00%, P=.850) despite the failures reported in 2 studies included in this review.

  • 3.

    Potential

CRediT authorship contribution statement

Kevin George Varghese: Conceptualization, Writing – original draft, Investigation, Data curation, Software, Visualization, Writing – review & editing. Nitasha Gandhi: Supervision, Resources, Project administration. Nirmal Kurian: Conceptualization, Methodology, Writing – review & editing, Investigation. Angleena Y. Daniel: Supervision, Resources. Kusha Dhawan: Investigation, Methodology. Meril Joseph: Investigation, Data curation. Mevin George Varghese: Investigation, Visualization, Data

  • M.C. Goiato et al.

    Implants in the zygomatic bone for maxillary prosthetic rehabilitation: a systematic review

    Int J Oral Maxillofac Surg

    (2014)

  • F. Wang et al.

    Reliability of four zygomatic implant-supported prostheses for the rehabilitation of the atrophic maxilla: a systematic review

    Int J Oral Maxillofac Implants

    (2015)

  • E.L. Agliardi et al.

    Immediate full-arch rehabilitation of the severely atrophic maxilla supported by zygomatic implants: a prospective clinical study with minimum follow-up of 6 years

    Int J Oral Maxillofac Implants

    (2017)

  • R. Davó et al.

    Quad zygoma: technique and realities

    Oral Maxillofac Clin North Am

    (2019)

  • E. Bedrossian et al.

    Immediate stabilization at stage II of zygomatic implants: rationale and technique

    JProsthet Dent

    (2001)

  • S.M. Parel et al.

    Remote implant anchorage for the rehabilitation of maxillary defects

    JProsthet Dent

    (2001)

  • E. Nyström et al.

    Reconstruction of the atrophic maxilla with interpositional bone grafting/Le fort I osteotomy and endosteal implants: a 11-16 year follow-up

    Int J Oral Maxillofac Surg

    (2009)

  • J. Jensen et al.

    Varying treatment strategies for reconstruction of maxillary atrophy with implants: results in 98 patients

    JOral Maxillofac Surg

    (1994)

  • E. Nystrom et al.

    10-year follow-up of onlay bone grafts and implants in severely resorbed maxillae

    Int J Oral Maxillofac Surg

    (2004)

  • E. Klemetti

    Areview of residual ridge resorption and bone density

    JProsthet Dent

    (1996)

  • C. Malevez et al.

    Use of zygomatic implants to deal with resorbed posterior maxillae

    Periodontol 2000

    (2003)

  • A. Sharma et al.

    Zygomatic implants/fixture: a systematic review

    (Video) Webinar Full Arch Immediate Loading with Zygomatic and Pterygoid Implants - Dr. Dan Holtzclaw

    JOral Implantol

    (2013)

  • D. van Steenberghe et al.

    The rehabilitation of the severely resorbed maxilla by simultaneous placement of autogenous bone grafts and implants: a 10-year evaluation

    Clin Oral Investig

    (1997)

  • M. Esposito et al.

    Effectiveness of sinus lift procedures for dental implant rehabilitation: a Cochrane systematic review

    Eur J Oral Implantol

    (2010)

  • P.I. Branemark

    The zygomatic fixture: clinical procedures

    (1998)

  • C.A. Landes et al.

    Zygoma implants for midfacial prosthetic rehabilitation using telescopes: 9-year follow-up

    Int J Prosthodont

    (2009)

  • P.I. Brånemark et al.

    Zygoma fixture in the management of advanced atrophy of the maxilla: technique and long-term results

    Scand J Plast Reconstr Surg Hand Surg

    (2004)

  • R. Davo et al.

    Immediate function of four zygomatic implants: a one-year report of a prospective study

    Eur J Oral Implantol

    (2010)

  • C. Aparicio et al.

    Reconstruction of the premaxilla with autogenous iliac bone in combination with osseointegrated implants

    Int J Oral Maxillofac Implants

    (1993)

  • K.W. Higuchi

    The zygomaticus fixture: an alternative approach for implant anchorage in the posterior maxilla

    Ann R Australas Coll Dent Surg

    (2000)

  • C. Aparicio et al.

    Zygomatic implants: indications, techniques and outcomes, and the zygomatic success code

    Periodontol 2000

    (2014)

  • D. Moher et al.

    Preferred reporting items for systematic reviews and meta-analyses: the Prisma statement

    PLoS Med

    (2009)

  • R. Davó et al.

    Clinical outcome of 42 patients treated with 81 immediately loaded zygomatic implants: a 12-to 42-month retrospective study

    Eur J Oral Implantol

    (2008)

  • R.M. Migliorança et al.

    Restoration of the edentulous maxilla using extrasinus zygomatic implants combined with anterior conventional implants: a retrospective study

    Int J Oral Maxillofac Implants

    (2011)

  • R. Davó et al.

    Prostheses supported by four immediately loaded zygomatic implants: a 3-year prospective study

    Eur J Oral Implantol

    (2013)

    • Three-dimensional finite element analysis of zygomatic implants for rehabilitation of patients with a severely atrophic maxilla

      2023, Journal of Prosthetic Dentistry

      Stresses applied to zygomatic implants have been determined to be transferred mainly to the zygomatic bone; however, consensus regarding the stress distribution pattern in the bone surrounding zygomatic implants has not yet been reached.

      The purpose of this 3-dimensional (3D) finite element analysis (FEA) study was to visually compare the stress distribution pattern in 2 different zygomatic implant treatment modalities and evaluate the effect of masseter musculature involvement.

      A 3D FEA craniofacial model was constructed from the computed tomography (CT) data of a selected patient with a severely atrophic edentulous maxilla. Modeled zygomatic and conventional implants were inserted into the craniofacial model supporting a prosthesis superstructure. Two types of treatment were considered in the study: 2 zygomatic implants placed bilaterally or 2 zygomatic implants placed in conjunction with at least 2 conventional implants at the anterior maxilla. The models were loaded with a vertical force of 150 N, a lateral force of 50 N, and a distributed occlusal force of 300 N applied to the insertion area of the masseter muscle. The stresses on and deformations of the bones and implants were then observed and compared with and without the involvement of the musculature component.

      The stresses were distributed efficiently along the vertical and horizontal facial buttresses, as in the dentate skull; however, a difference in distribution pattern was observed when the models were loaded without applying the muscle component. The maximum deformation of bones surrounding the implants occurred in the abutment connection of the conventional anterior implant in the model with an additional conventional anterior implant.

      The FEA revealed the stresses were distributed efficiently along the vertical and horizontal facial buttresses, as in the dentate skull. However, the stresses in both models were concentrated in the zygomatic bone when incorporating the muscle component. Therefore, incorporating muscular force into FEA studies could affect the analysis result.

      (Video) PTERYGOID IMPLANTS IN THE TREATMENT OF TOTALLY AND PARTIALLY EDENTULOUS MAXILLA
    • Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

      2022, Journal of Prosthetic Dentistry

      Citation Excerpt :

      In addition to articles selected for detailed review, a sizable number of excellent general reviews, systematic reviews, meta-analyses, and helpful clinical descriptive articles were also published addressing issues important to prosthodontics. Although it is impractical to provide detailed analysis on all these publications, they are listed here, by the topic area, for the reader’s convenience and include the following: general prosthodontic considerations,5-7 conventional fixed prosthodontics,8-14 conventional removable prosthodontics,15-30 general implant considerations,31-59 implant-fixed prosthodontics,60-76 implant removable prosthodontics,77-79 implant complications,80-84 implant integration,85-93 preprosthetic and implant surgery,94-115 peri-implant tissues and disease,116-131 dental occlusion,132-146 dental impressions,147 digital dentistry,148-150 materials science,151-166 endodontic-prosthodontic topics,167-171 periodontal-prosthodontic topics,172-178 operative dentistry,179 geriatric dentistry,180-193 pathology and oral medicine (OM),194-214 dental radiology and imaging,215-231 adolescent and growing patients,232-243 bruxism,244 mastication,245 dental caries,246-250 therapeutic outcomes,251-261 patient management,262-267 research methods,268-270 COVID-19–related topics,271-276 dental education,277 sleep and sleep disordered breathing,278-280 and the temporomandibular joint (TMJ), temporomandibular disorder (TMD), and orofacial pain (OFP).281-299 Peri-implant bone loss coincident with occlusal loading is thought to be related to poorly controlled stress concentration.

      The Scientific Investigation Committee of the American Academy of Restorative Dentistry offers this review of the 2021 dental literature in restorative dentistry to inform busy dentists regarding noteworthy scientific and clinical progress over the past year. Each member of the committee brings discipline-specific expertise to coverage of this broad topical area. Specific subject areas addressed, in order of the appearance in this report, include COVID-19 and the dental profession (new); prosthodontics; periodontics, alveolar bone, and peri-implant tissues; implant dentistry; dental materials and therapeutics; occlusion and temporomandibular disorders; sleep-related breathing disorders; oral medicine and oral and maxillofacial surgery; and dental caries and cariology. The authors focused their efforts on reporting information likely to influence daily dental treatment decisions with an emphasis on future trends in dentistry. With the tremendous volume of dentistry and related literature being published daily, this review cannot possibly be comprehensive. Rather, its purpose is to update interested readers and provide important resource material for those interested in pursuing greater details on their own. It remains our intent to assist colleagues in negotiating the extensive volume of important information being published annually. It is our hope that readers find this work useful in successfully managing the patients and dental problems they encounter.

    • Biomechanical evaluation of custom-made short implants with wing retention applied in severe atrophic maxillary posterior region restoration: A three-dimensional finite element analysis

      2023, Frontiers in Bioengineering and Biotechnology

    • Specially designed and CAD/CAM manufactured allogeneic bone blocks using for augmentation of a highly atrophic maxilla show a stable base for an all-on-six treatment concept: a case report

      2022, Maxillofacial Plastic and Reconstructive Surgery

    • Misfit of Implant-Supported Zirconia (Y-TZP) CAD-CAM Framework Compared to Non-Zirconia Frameworks: A Systematic Review

      2022, Medicina (Lithuania)

    • Rehabilitation of Patients with Compromised Ridge Support Using Immediately Loaded Corticobasal Implant-supported Prostheses: A Prospective Observational Study

      2022, Journal of Contemporary Dental Practice

    • Research article

      Zygomatic Implants Operative Consideration to Minimize Technical Errors, Complications, and Their Management

      Atlas of the Oral and Maxillofacial Surgery Clinics, Volume 29, Issue 2, 2021, pp. 277-289

      (Video) Dental Injuries and Facial Fractures | National Fellow Online Lecture Series
    • Research article

      The Zygoma Anatomy-Guided Approach for Placement of Zygomatic Implants

      Atlas of the Oral and Maxillofacial Surgery Clinics, Volume 29, Issue 2, 2021, pp. 203-231

    • Research article

      Virtual quad zygoma implant placement using cone beam computed tomography: sufficiency of malar bone volume, intraosseous implant length, and relationship to the sinus according to the degree of alveolar bone atrophy

      International Journal of Oral and Maxillofacial Surgery, Volume 47, Issue 2, 2018, pp. 252-261

      The objective of this study was to investigate the malar bone volume and length that a zygomatic implant can engage, and the relationship to the sinus according to the degree of alveolar bone atrophy. A three-dimensional evaluation was performed using cone beam computed tomography scans from 23 patients with a totally edentulous maxilla; quad zygoma implants were virtually placed. The predictor variable was the amount of malar bone volume and length that a zygomatic implant can engage. The primary outcome variable was the relationship to the sinus according to the degree of alveolar bone atrophy. Other variables were the residual alveolar bone height to the floor of the sinus and the nasal cavity. The mean volume of malar bone engaged in this sample of 92 zygomatic implants was 0.19±0.06cm3. The implant had an extrasinus path in 60.9% of cases, a parasinus path in 25%, and an intrasinus path in 14.1%. The results suggest that the average volume of malar bone engaged by a zygomatic implant is constant regardless of implant position and the degree of alveolar bone atrophy. As alveolar atrophy increases, the trajectory of the implant becomes more parasinus and intrasinus. The examiners were able to find enough bone to adequately distribute the implants in all cases.

    • Research article

      Quad Zygoma: Technique and Realities

      Oral and Maxillofacial Surgery Clinics of North America, Volume 31, Issue 2, 2019, pp. 285-297

    • Research article

      Real-Time Navigation in Zygomatic Implant Placement: Workflow

      Oral and Maxillofacial Surgery Clinics of North America, Volume 31, Issue 3, 2019, pp. 357-367

    • Research article

      Application of Real-Time Surgical Navigation for Zygomatic Implant Insertion in Patients With Severely Atrophic Maxilla

      Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 1, 2018, pp. 80-87

      Computer-aided treatment technology has extended its applications to oral implantology. This report describes the authors' initial clinical experience on the application of a commercially available navigation system (VectorVision) in zygomatic implant (ZI) insertion in the severely atrophic maxilla.

      This was a retrospective longitudinal study. Eligible patients with maxillary edentulism who were treated with ZI placement were enrolled. Treatment planning was performed on the computer based on previously obtained 3-dimensional imaging data. The surgical procedure was carried out under the guidance of a surgical navigation system. The outcome variable was safety and additional variables were ZI survival rate and radiologic bone-to-implant contact (rBIC) area in the zygoma. Statistical analysis was performed with SPSS 16.0 for Windows (SPSS, Inc, Chicago, IL).

      Fifteen patients (8 men, 7 women; age range, 30 to 69yr; average age, 43±3.5yr) were eligible for the study and were enrolled from May 2015 through September 2016. Of the included patients, each of 4 patients received 1 ZI on each side of the zygomatic bone and 2 to 4 standard implants in the edentulous anterior maxilla; the other 11 received a ZI “quad approach” without standard implant insertion. All ZIs were anchored in the site of the maxillary alveolar process and zygomatic bone, and no critical anatomic structure injuries occurred during insertion and postoperative radiographic examination. All ZIs achieved osseointegration, for an overall survival rate of 100% after early healing. The overall rBIC area of ZIs in the study was 4.1 to 24.7mm (average, 14.5±4.6mm).

      For the limited clinical cases treated in this study, the procedure for ZI placement was feasible and reliable with the guidance of the surgical navigation system. In addition, the potential risk of complications was minimized and ZIs were placed to make the best possible use of the available bone volume.

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